Why do injuries continue to hurt , even when they are healing ? New inquiry reveals why we feel certain sort of post - injury pain in the ass – and possibly how to stop it .
A group of researcher in San Francisco published a paper in this week ’s Nature that explores one of the many mystery about annoyance : Why do light signature near a recent injury feel so painful ? The answer is more complicated than you might think . These post - trauma pains , called “ mechanical pain , ” may be stimulate by a unlike mechanics than pain link up with injury itself . The researchers discovered that mechanical hurting wizard are return from the injury web site to the spinal electric cord via a chemical cognitive process that can easily be interrupted – just by blocking production of a protein call VGLUT3 .
They free-base their analysis on experiments that proved mouse lacking VGLUT3 get far less mechanical pain than their VGLUT3 - producing cohort .
What this finding suggests is that we might be on the scepter of discovering a unexampled stock of painkillers that do n’t cast down the entire flighty scheme ( and fuzz out your brain ) , but or else interrupt specific pain footpath . In essence , you ’d have a highly - targeted analgesic that would prevent your injuries from hurting while they heal . You could dull that pain sensation without dull your head – and hopefully without addiction .
The investigator have yet to test on humans , but they do suggest that this could be a bright area of research for painfulness management .
viaNature
paradigm of VGLUT3 in inner ear jail cell ( it ’s in red ) viaHuman Molecular Genetics
DrugsNeuroscienceScience
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